Cerebral blood flow in mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes

The precise mechanism of neurological symptoms with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS) is still controversial. We investigated the correlation between strokelike episodes and cerebral blood flow in two patients with MELAS and discuss the pathogen...

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Bibliographic Details
Published in:Stroke (1970) 1993-02, Vol.24 (2), p.304-309
Main Authors: OOIWA, Y, UEMATSU, Y, TERADA, T, NAKAI, K, ITAKURA, T, KOMAI, N, MORIWAKI, H
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Cerebrovascular Circulation
Cerebrovascular Disorders - etiology
Diseases of striated muscles. Neuromuscular diseases
Female
Humans
Magnetic Resonance Imaging
Medical sciences
MELAS Syndrome - diagnostic imaging
MELAS Syndrome - etiology
MELAS Syndrome - physiopathology
Neurology
Tomography, X-Ray Computed - methods
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Summary:The precise mechanism of neurological symptoms with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS) is still controversial. We investigated the correlation between strokelike episodes and cerebral blood flow in two patients with MELAS and discuss the pathogenesis of strokelike episodes with MELAS. Cerebral dynamic computed tomography and cerebral angiography were used to measure cerebral circulation in the first case, that of a 20-year-old woman with MELAS. The second subject was a 13-year-old female who was studied with xenon-enhanced computed tomography. The cerebral blood flow studies were performed 3-72 hours after the onset of strokelike episodes. Serial cerebral angiography, dynamic computed tomography, and xenon-enhanced computed tomography showed vasodilation localized in the affected cerebral cortexes during strokelike episodes, without any reduction in regional cerebral blood flow. Our study suggests that the strokelike episodes associated with MELAS are different in origin from ischemic stroke.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.str.24.2.304