Changes in α -glucosidase activities along the jejunal-ileal axis of normal rats by the α -glucosidase inhibitor miglitol

Abstract Miglitol, an α -glucosidase inhibitor that inhibits postprandial hyperglycemia by delaying carbohydrate digestion and absorption along the jejunal-ileal axis, has recently been approved for use in patients with type 2 diabetes mellitus. Miglitol treatment may lead to increased α -glucosidas...

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Published in:Metabolism, clinical and experimental clinical and experimental, 2010-10, Vol.59 (10), p.1442-1447
Main Authors: Mochizuki, Kazuki, Hanai, Emiko, Suruga, Kazuhito, Kuranuki, Sachi, Goda, Toshinao
Format: Article
Language:English
Subjects:
1-Deoxynojirimycin - analogs & derivatives
1-Deoxynojirimycin - pharmacology
alpha-Glucosidases - metabolism
Animals
Biological and medical sciences
Cecum - drug effects
Cecum - metabolism
Dietary Supplements
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Endocrinology & Metabolism
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Glycoside Hydrolase Inhibitors
Hypoglycemic Agents - pharmacology
Ileum - drug effects
Ileum - metabolism
Intestinal Mucosa - drug effects
Intestinal Mucosa - metabolism
Jejunum - drug effects
Jejunum - metabolism
Male
Rats
Rats, Wistar
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Abstract Miglitol, an α -glucosidase inhibitor that inhibits postprandial hyperglycemia by delaying carbohydrate digestion and absorption along the jejunal-ileal axis, has recently been approved for use in patients with type 2 diabetes mellitus. Miglitol treatment may lead to increased α -glucosidase activities toward the ileum because carbohydrate flow toward the ileum increases. However, it is not yet known if miglitol treatment alters the α -glucosidase activities along the jejunal-ileal axis. In this study, we examined the effects of miglitol supplementation for 3 or 7 days on α -glucosidase activities along the jejunal-ileal axis of Wistar rats. Supplementation with miglitol for 3 or 7 days in rats increased tissue weights of the lower jejunum and ileum, but did not alter tissue weights of the upper jejunum and cecum or the contents of the cecum. Furthermore, supplementation with miglitol for 7 days reduced the activities of isomaltase and maltase in the upper jejunum and increased the activities of sucrase, isomaltase, and maltase in the lower jejunum and ileum. These results suggest that the delay in carbohydrate digestion and absorption along the jejunal-ileal axis by miglitol supplementation in rats is associated with increased α -glucosidase activities toward the ileum.
ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2010.01.008