Epstein-Barr virus (EBV) genotypes among human immunodeficiency virus (HIV)-related B-cell Lymphomas and B-cell post-transplant lymphoproliferative disorders (B-PTLD) - late-onset lymphomas, especially in the HIV setting, are associated with type-B-EBV

We investigated 26 B‐cell post‐transplant lymphoproliferative disorders (B‐PTLD) and 15 human immunodeficiency virus‐related aggressive B‐cell lymphomas (HIV‐BCL) from England that were associated with Epstein–Barr virus (EBV) for the polymorphic sequences of the EBV‐encoded nuclear antigen 3C (EBNA...

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Bibliographic Details
Published in:European journal of haematology 2010-09, Vol.85 (3), p.227-230
Main Authors: Ibrahim, Hazem A. H., Menasce, Lia P., Pomplun, Sabine, Burke, Margaret, Bower, Mark, Naresh, Kikkeri N.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Child
Child, Preschool
Epstein-Barr virus
Female
Genotype
Herpesvirus 4, Human - genetics
Herpesvirus 4, Human - pathogenicity
Herpesvirus 4, Human - physiology
HIV - physiology
Human immunodeficiency virus
Humans
lymphoma
Lymphoma, B-Cell - pathology
Lymphoma, B-Cell - virology
Lymphoproliferative Disorders - pathology
Lymphoproliferative Disorders - virology
Male
Middle Aged
Organ Transplantation
post-transplant lymphoproliferative disorders
Young Adult
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Summary:We investigated 26 B‐cell post‐transplant lymphoproliferative disorders (B‐PTLD) and 15 human immunodeficiency virus‐related aggressive B‐cell lymphomas (HIV‐BCL) from England that were associated with Epstein–Barr virus (EBV) for the polymorphic sequences of the EBV‐encoded nuclear antigen 3C (EBNA3C) gene to distinguish the two different EBV strains. Type‐A‐EBV was identified in 92% of B‐PTLDS and in 53% of HIV‐BCL (P = 0.003). Among HIV‐BCL, patients associated with type‐B‐EBV had been HIV positive for significantly longer when compared to those associated with type‐A (P = 0.037) although there were no correlations with ethnicity, CD4 cell counts or plasma HIV viral load.
ISSN:0902-4441
1600-0609
DOI:10.1111/j.1600-0609.2010.01460.x