Cytogenesis in the adult rat dentate gyrus is increased following kindled seizures but is unaltered in pharmacological models of absence seizures

Abstract The production of new neurons continues throughout adulthood in the dentate gyrus of the hippocampal formation, and is believed to play a role in hippocampus-dependent learning and memory. Seizure-induced changes in adult neurogenesis have been examined primarily in convulsive rodent seizur...

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Bibliographic Details
Published in:Epilepsy & behavior 2010-07, Vol.18 (3), p.179-185
Main Authors: Scott, B.W, Chan, K.F.Y, Wong, G, Ahmed, M, Chieverton, L, Liu, R.R, Wood, J, Burnham, W.M
Format: Article
Language:English
Subjects:
4-Butyrolactone - pharmacology
4-Butyrolactone - therapeutic use
Animals
Animals, Newborn
Anticholesteremic Agents - therapeutic use
AY-9944
Bromodeoxyuridine - metabolism
Cell Count - methods
Cell proliferation
Cholesterol
Dentate Gyrus - physiopathology
Disease Models, Animal
Electroencephalography - methods
Epilepsy
Epilepsy, Absence - drug therapy
Epilepsy, Absence - etiology
Epilepsy, Absence - pathology
Epileptic discharge
Gene Expression Regulation
Hippocampus
Kindling, Neurologic - physiology
Male
Memory
Nerve Tissue Proteins - metabolism
Neurogenesis
Neurogenesis - drug effects
Neurogenesis - physiology
Neurology
Rats
Rats, Long-Evans
trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride - therapeutic use
γ-hydroxybutyrate
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Summary:Abstract The production of new neurons continues throughout adulthood in the dentate gyrus of the hippocampal formation, and is believed to play a role in hippocampus-dependent learning and memory. Seizure-induced changes in adult neurogenesis have been examined primarily in convulsive rodent seizure models, but not in models of nonconvulsive absence seizures. This study examined progenitor cell proliferation in the γ-hydroxybutyrate (GHB) model of typical absence seizures and the AY-9944 model of atypical absence seizures, and compared these results with changes seen in the rat amygdala kindling model. Kindled subjects were found to have 189% more proliferating cells than sham-kindled control subjects, whereas no significant difference was found between the GHB or AY-9944 model and control subjects. These results suggest that changes in adult neurogenesis in models of absence seizures do not occur, and that seizure-induced enhancement of neurogenesis could depend on the characteristics of the seizure discharge.
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2010.04.020