Metastasis-associated protein S100A4-a potential prognostic marker for colorectal cancer

Background and Objectives Expression of S100A4, a small calcium‐binding protein, in breast, oesophagus and gall bladder cancers is shown to be associated with adverse clinical outcome. We retrospectively examined the correlation of S100A4 expression and outcome in patients with colorectal cancer. Me...

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Bibliographic Details
Published in:Journal of surgical oncology 2006-05, Vol.93 (6), p.498-503
Main Authors: Hemandas, A.K., Salto-Tellez, M., Maricar, S.H., Leong, A.F.P.K., Leow, C.K.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
colorectal cancer
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Female
Humans
Immunohistochemistry
Liver Neoplasms - secondary
Lymph Nodes - pathology
Lymphatic Metastasis
Male
metastasis
Middle Aged
Neoplasm Staging
Prognosis
Retrospective Studies
S100 Calcium-Binding Protein A4
S100 Proteins - biosynthesis
S100A4
survival
Survival Analysis
Treatment Outcome
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Summary:Background and Objectives Expression of S100A4, a small calcium‐binding protein, in breast, oesophagus and gall bladder cancers is shown to be associated with adverse clinical outcome. We retrospectively examined the correlation of S100A4 expression and outcome in patients with colorectal cancer. Methods Tissue sections from 54 patients with Dukes B, C and D cancers operated on between 1995 and 1998 were stained with anti‐S100A4 antibody. The S100A4 expression profile was correlated to the clinico‐pathological details. Results There were 31 males and 23 females (mean age 65.94 years +/− 12.29). Dukes stage, >4 positive lymph node status and S100A4 expression were significantly associated with poorer survival. The 3 years survival of patients whose tumour stained positive for S100A4 was 62.85% compared to 93.75% for those stained negative (P 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.20460