Early changes in experimental osteoarthritis using the Pond-Nuki dog model: technical procedure and initial results of in vivo MR imaging

The purpose of this study was to prove the feasibility of combining in vivo MR imaging with the Pond-Nuki animal model for the evaluation of osteoarthritis. In an experimental study, 24 beagle dogs underwent transection of the anterior cruciate ligament of the left leg (modified Pond-Nuki model). Th...

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Bibliographic Details
Published in:European radiology 2005-02, Vol.15 (2), p.390-394
Main Authors: Libicher, Martin, Ivancic, Mate, Hoffmann, Michael, Hoffmann, Volker, Wenz, Wolfram
Format: Article
Language:English
Subjects:
Animals
Bone marrow
Cartilage, Articular - pathology
Chi-Square Distribution
Disease Models, Animal
Dogs
Feasibility Studies
Knee
Ligaments
Magnetic Resonance Imaging - methods
Osteoarthritis, Knee - pathology
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Summary:The purpose of this study was to prove the feasibility of combining in vivo MR imaging with the Pond-Nuki animal model for the evaluation of osteoarthritis. In an experimental study, 24 beagle dogs underwent transection of the anterior cruciate ligament of the left leg (modified Pond-Nuki model). The dogs were randomly assigned into four groups and examined by MRI after 6, 12, 24 and 48 weeks. MR imaging of both knees was performed under general anesthesia with the contralateral joint serving as control. In group 1 (6 weeks postoperatively), the first sign detected on MRI was subchondral bone marrow edema in the posteromedial tibia. After 12 weeks, erosion of the posteromedial tibial cartilage could be observed, followed by meniscus degeneration and osteophytosis after 24 and 48 weeks. The contralateral knee joint showed transient joint effusion, but no significant signs of internal derangement (P
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-004-2486-y