Narrowband ultraviolet B treatment improves vitamin D balance and alters antimicrobial peptide expression in skin lesions of psoriasis and atopic dermatitis

Summary Background  Narrowband ultraviolet B (NB‐UVB) is a routine treatment for psoriasis and atopic dermatitis (AD) but its effect on vitamin D balance is not well studied. Objectives  To examine whether NB‐UVB treatment in winter improves vitamin D balance in psoriasis and AD, and to study the ef...

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Bibliographic Details
Published in:British journal of dermatology (1951) 2010-08, Vol.163 (2), p.321-328
Main Authors: Vähävihu, K., Ala-Houhala, M., Peric, M., Karisola, P., Kautiainen, H., Hasan, T., Snellman, E., Alenius, H., Schauber, J., Reunala, T.
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Adult
Allergic diseases
Antimicrobial Cationic Peptides - metabolism
Antimicrobial peptides
Atopic dermatitis
beta-Defensins - metabolism
Biological and medical sciences
calcidiol
Calcifediol - blood
cathelicidins
Cathelicidins - metabolism
Cytokines
Cytokines - metabolism
Defensins
Dermatitis, Atopic - metabolism
Dermatitis, Atopic - radiotherapy
Dermatology
Female
Humans
Immunopathology
Interleukin 17
Male
Medical sciences
Middle Aged
Psoriasis
Psoriasis - metabolism
Psoriasis - radiotherapy
Psoriasis. Parapsoriasis. Lichen
Radioimmunoassay
Reverse Transcriptase Polymerase Chain Reaction
Seasons
Skin allergic diseases. Stinging insect allergies
Skin diseases
U.V. radiation
ultraviolet B radiation
Ultraviolet Therapy - methods
Vitamin D
Vitamin D - metabolism
Vitamin D - radiation effects
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Summary:Summary Background  Narrowband ultraviolet B (NB‐UVB) is a routine treatment for psoriasis and atopic dermatitis (AD) but its effect on vitamin D balance is not well studied. Objectives  To examine whether NB‐UVB treatment in winter improves vitamin D balance in psoriasis and AD, and to study the effects of NB‐UVB on antimicrobial peptide and cytokine expression in the skin. Methods  Eighteen adult patients with psoriasis, 18 with AD and 15 healthy subjects received a total of 15 NB‐UVB exposures on the whole body, given three times a week. Serum calcidiol (25‐hydroxyvitamin D) was measured by radioimmunoassay. Antimicrobial peptide and cytokine expression in skin lesions was examined by real‐time quantitative polymerase chain reaction. Results  At onset 16 (89%) patients with psoriasis, 17 (94%) patients with AD and eight (53%) healthy subjects had vitamin D insufficiency (calcidiol
ISSN:0007-0963
1365-2133
DOI:10.1111/j.1365-2133.2010.09767.x