Diffuse leptomeningeal seeding from benign choroid plexus papilloma

Choroid plexus papillomas (CPP) are rare intracranial tumours with a favourable long-term outcome after surgical excision. Although they are histologically benign, local recurrences may occasionally occur, but leptomeningeal dissemination is exceptional. We report an unusual example of a fourth vent...

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Bibliographic Details
Published in:Acta neurochirurgica 2007-12, Vol.149 (12), p.1229-36; discussion 1236-7
Main Authors: Ortega-Martínez, M, Cabezudo-Artero, J M, Fernández-Portales, I, Pimentel, J J, Gómez de Tejada, R
Format: Article
Language:English
Subjects:
Adult
Biomarkers, Tumor - analysis
Biopsy
Cerebral Ventricle Neoplasms - pathology
Cerebral Ventricle Neoplasms - surgery
Disease Progression
Fatal Outcome
Female
Fourth Ventricle - pathology
Fourth Ventricle - surgery
Humans
Ki-67 Antigen - analysis
Laminectomy
Magnetic Resonance Imaging
Meningeal Neoplasms - pathology
Meningeal Neoplasms - secondary
Meningeal Neoplasms - surgery
Meninges - pathology
Neoplasm Seeding
Papilloma, Choroid Plexus - pathology
Papilloma, Choroid Plexus - surgery
Reoperation
S100 Proteins - analysis
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Summary:Choroid plexus papillomas (CPP) are rare intracranial tumours with a favourable long-term outcome after surgical excision. Although they are histologically benign, local recurrences may occasionally occur, but leptomeningeal dissemination is exceptional. We report an unusual example of a fourth ventricle choroid plexus papilloma with diffuse leptomeningeal seeding. Neither the initial tumour nor the recurrence showed malignant histological features. Treatment with systemic and intrathecal chemotherapy was ineffective in this patient. We review the literature concerning leptomeningeal dissemination of benign choroid plexus papillomas.
ISSN:0001-6268
0942-0940
DOI:10.1007/s00701-007-1292-0