Incidence of Malignancies in HIV-Infected Patients and Prognostic Role of Current CD4 Cell Count: Evidence from a Large Italian Cohort Study

The incidence of and predictors of acquired immunodeficiency syndrome-defining malignancies (ADMs) and non-ADM (NADMs) were evaluated in a large Italian cohort. The incidence of ADM and NADM was 5.0 cases per 1000 personyears of follow-up (95% confidence interval, 4.3-5.8 cases per 1000 person-years...

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Bibliographic Details
Published in:	Clinical infectious diseases 2010-05, Vol.50 (9), p.1316-1321
Main Authors:	Prosperi, M. C. F., Cozzi-Lepri, A., Castagna, A., Mussini, C., Murri, R., Giacometti, A., Torti, C., Costantini, A., Narciso, P., Ghinelli, F., Antinori, A., Monforte, A. d'Arminio
Format:	Article
Language:	eng
Subjects:	Adult Advisory boards AIDS Antiretrovirals Art therapy Cancer CD4 Lymphocyte Count Cells Cohort Studies Female Glycoproteins Highly active antiretroviral therapy HIV HIV Infections - complications HIV/AIDS Human immunodeficiency virus Humans Incidence Infectious diseases Italy - epidemiology Male Nadir Neoplasms - epidemiology Prognosis Statistical median Studies
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Summary:	The incidence of and predictors of acquired immunodeficiency syndrome-defining malignancies (ADMs) and non-ADM (NADMs) were evaluated in a large Italian cohort. The incidence of ADM and NADM was 5.0 cases per 1000 personyears of follow-up (95% confidence interval, 4.3-5.8 cases per 1000 person-years of follow-up) and 2.4 cases per 1000 person-years of follow-up (95% confidence interval, 1.9-3.1 cases per 1000 person-years of follow-up), respectively. Lower current CD4 cell count was an independent predictor of developing malignancies, with the association being stronger for ADM than for NADM.
ISSN:	1058-4838 1537-6591