Pyrrolidinones from the Ascomycete Fungus Albonectria rigidiuscula

The new pyrrolidinones, rigidiusculamides A−D (1−4), have been isolated from the crude extract of the ascomycete fungus Albonectria rigidiuscula. The structures of these compounds were elucidated primarily by NMR experiments. The absolute configuration of the 3,4-diol moieties in 1 and 4 was assigne...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2009-12, Vol.72 (12), p.2184-2187
Main Authors: Li, Jian, Liu, Shuchun, Niu, Shubin, Zhuang, Wenying, Che, Yongsheng
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Ascomycetes
Ascomycota - chemistry
Biological and medical sciences
China
Drug Screening Assays, Antitumor
General pharmacology
HeLa Cells
Humans
K562 Cells
Medical sciences
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Pyrrolidinones - chemistry
Pyrrolidinones - isolation & purification
Pyrrolidinones - pharmacology
Trees - microbiology
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Summary:The new pyrrolidinones, rigidiusculamides A−D (1−4), have been isolated from the crude extract of the ascomycete fungus Albonectria rigidiuscula. The structures of these compounds were elucidated primarily by NMR experiments. The absolute configuration of the 3,4-diol moieties in 1 and 4 was assigned using Snatzke’s method. Compounds 1 and 2 showed modest cytotoxicity against the human tumor cell lines HeLa and MCF-7.
ISSN:0163-3864
1520-6025
DOI:10.1021/np900619z