Labdane Diterpenoid Glycosides from Alpinia densespicata and Their Nitric Oxide Inhibitory Activities in Macrophages

Four new labdane diterpene glycosides (1−4) named alpindenosides A, B, C, and D, two new norditerpene glycosides (5, 6) named noralpindenosides A and B, and three known flavonoid glycosides (7−9) have been isolated from the stems of Alpinia densespicata. Structural elucidation of compounds 1−6 was b...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2009-06, Vol.72 (6), p.1097-1101
Main Authors: Kuo, Yu-Jen, Hsiao, Ping-Chun, Zhang, Li-Jie, Wu, Ming-Der, Liang, Yu-Han, Ho, Hsiu-O, Kuo, Yao-Haur
Format: Article
Language:English
Subjects:
alpindenosides
Alpinia
Alpinia - chemistry
Alpinia densespicata
Animals
anti-inflammatory activity
Biological and medical sciences
chemical constituents of plants
chemical structure
cytotoxicity
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - pharmacology
diterpenoids
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
General pharmacology
glycosides
Glycosides - chemistry
Glycosides - pharmacology
HeLa Cells
human cell lines
Humans
KB Cells
labdane diterpenoids
Lipopolysaccharides - pharmacology
macrophages
Macrophages - drug effects
Medical sciences
medicinal properties
Mice
Molecular Structure
neoplasms
nitric oxide
Nitric Oxide - antagonists & inhibitors
noralpindenosides
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phytochemicals
spectroscopy
stems
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Four new labdane diterpene glycosides (1−4) named alpindenosides A, B, C, and D, two new norditerpene glycosides (5, 6) named noralpindenosides A and B, and three known flavonoid glycosides (7−9) have been isolated from the stems of Alpinia densespicata. Structural elucidation of compounds 1−6 was based on spectroscopic data. Compounds 1−9 all exhibited moderate NO inhibitory activities, whereas they were noncytotoxic at 20 μM against several human tumor cell lines.
ISSN:0163-3864
1520-6025
DOI:10.1021/np900019n