Immunogenicity of Toxins during Staphylococcus aureus Infection

Background Toxins are important Staphylococcus aureus virulence factors, but little is known about their immunogenicity during infection. Here, additional insight is generated. Methods Serum samples from 206 S. aureus-infected patients and 201 hospital-admitted control subjects were analyzed for imm...

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Bibliographic Details
Published in:Clinical infectious diseases 2010-01, Vol.50 (1), p.61-68
Main Authors: Verkaik, Nelianne J., Dauwalder, Olivier, Antri, Kenza, Boubekri, Ilhem, de Vogel, Corné P., Badiou, Cédric, Bes, Michèle, Vandenesch, Francçois, Tazir, Mohamed, Hooijkaas, Herbert, Verbrugh, Henri A., van Belkum, Alex, Etienne, Jerome, Lina, Gerard, Ramdani-Bouguessa, Nadjia, van Wamel, Willem J.B.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies
Antibodies, Bacterial - immunology
ARTICLES AND COMMENTARIES
Bacterial diseases
Bacterial Toxins - genetics
Bacterial Toxins - immunology
Biological and medical sciences
Bones
Case-Control Studies
Child
Child, Preschool
Enterotoxins
Female
Fluorescence
Genes
Human bacterial diseases
Humans
Immune response
Immunoglobulin G - immunology
Immunoglobulins
Infant
Infant, Newborn
Infections
Infectious diseases
Leukocidins
Logistic Models
Male
Medical sciences
Middle Aged
Prevalence
Reproducibility of Results
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus
Staphylococcus aureus
Staphylococcus aureus - genetics
Staphylococcus aureus - immunology
Staphylococcus aureus - pathogenicity
Staphylococcus infections
Statistics, Nonparametric
Toxicity
Toxins
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Description
Summary:Background Toxins are important Staphylococcus aureus virulence factors, but little is known about their immunogenicity during infection. Here, additional insight is generated. Methods Serum samples from 206 S. aureus-infected patients and 201 hospital-admitted control subjects were analyzed for immunoglobulin (Ig) G binding to 20 toxins, using flow-cytometry based technology. Antibody levels were associated with polymerase chain reaction-defined presence of toxin genes in homologous S. aureus isolates. Results IgG levels directed to exfoliative toxin (ET) A, ETB, ghemolysin B (HlgB), leukocidin (Luk) D, LukE, LukS, staphylococcal enterotoxin (SE) A, SEE, SEH, SEI, and SElM were higher in S. aureus-infected patients than in control subjects (P
ISSN:1058-4838
1537-6591
DOI:10.1086/648673