Porcine reproductive and respiratory syndrome virus entry into the porcine macrophage

Porcine reproductive and respiratory syndrome virus (PRRSV) emerged in the late 1980s and rapidly became one of the most significant viral pathogens in the swine industry. In vivo, the virus shows a very narrow cell tropism and targets specific subsets of porcine macrophages. The entry of PRRSV into...

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Bibliographic Details
Published in:Journal of general virology 2010-07, Vol.91 (Pt 7), p.1659-1667
Main Authors: Van Breedam, Wander, Delputte, Peter L, Van Gorp, Hanne, Misinzo, Gerald, Vanderheijden, Nathalie, Duan, Xiaobo, Nauwynck, Hans J
Format: Article
Language:English
Subjects:
Animals
Macrophages - physiology
Macrophages - virology
Porcine respiratory and reproductive syndrome virus
Porcine respiratory and reproductive syndrome virus - physiology
Swine
Viral Tropism - physiology
Virus Internalization
Virus Replication - physiology
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Summary:Porcine reproductive and respiratory syndrome virus (PRRSV) emerged in the late 1980s and rapidly became one of the most significant viral pathogens in the swine industry. In vivo, the virus shows a very narrow cell tropism and targets specific subsets of porcine macrophages. The entry of PRRSV into its host cell is the first crucial step in infection and has been the focus of many fundamental studies. This review provides a comprehensive overview of the current knowledge on PRRSV entry into the porcine macrophage, covering virus binding, internalization and genome release, and integrates these findings into a general model of the entry process.
ISSN:0022-1317
1465-2099
1465-2099
DOI:10.1099/vir.0.020503-0