Polyneuropathy attributes : a comparison between patients with anti-MAG and anti-sulfatide antibodies

Thirty-two patients with a peripheral neuropathy and paraproteinemia were tested for IgM antibodies against myelin-associated protein (MAG) and sulfatide by means of enzyme-linked immunosorbent assay. Nine patients (28 %) had increased anti-sulfatide IgM antibodies and showed a chronic, slowly progr...

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Bibliographic Details
Published in:Journal of neurology 2000-10, Vol.247 (10), p.767-772
Main Authors: ERB, S, FERRACIN, F, FUHR, P, RÖSLER, K. M, HESS, C. W, KUNTZER, T, BOGOUSSLAVSKY, J, SZTAJZEL, R, STECK, A. J
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Chronic Disease
Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction
Disease Progression
Electrophysiology
Female
Humans
Immunoglobulin M - immunology
Male
Medical sciences
Middle Aged
Motor Skills Disorders
Myelin-Associated Glycoprotein - analysis
Myelin-Associated Glycoprotein - immunology
Nervous system (semeiology, syndromes)
Neurology
Peripheral Nervous System Diseases - immunology
Peripheral Nervous System Diseases - physiopathology
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Summary:Thirty-two patients with a peripheral neuropathy and paraproteinemia were tested for IgM antibodies against myelin-associated protein (MAG) and sulfatide by means of enzyme-linked immunosorbent assay. Nine patients (28 %) had increased anti-sulfatide IgM antibodies and showed a chronic, slowly progressive, distally pronounced, and symmetric polyneuropathy with sensory to sensory-motor impairment, ataxia, hyporeflexia, and axonal involvement in electrophysiological studies. Ten patients (31 %) with increased anti-MAG antibodies had a similar, homogeneous polyneuropathy syndrome but presented with demyelinating features. A weak cross-reactivity between anti-MAG and anti-sulfatide antibodies was present in only three patients. In conclusion, although the two neuropathy groups clearly differed in their electrophysiological features, their clinical presentation was rather similar.
ISSN:0340-5354
1432-1459
DOI:10.1007/s004150070090