Broca's region: linking human brain functional connectivity data and non-human primate tracing anatomy studies

Brodmann areas 6, 44 and 45 in the ventrolateral frontal cortex of the left hemisphere of the human brain constitute the anterior language production zone. The anatomical connectivity of these areas with parietal and temporal cortical regions was recently examined in an autoradiographic tract‐tracin...

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Bibliographic Details
Published in:The European journal of neuroscience 2010-08, Vol.32 (3), p.383-398
Main Authors: Kelly, Clare, Uddin, Lucina Q., Shehzad, Zarrar, Margulies, Daniel S., Castellanos, F. Xavier, Milham, Michael P., Petrides, Michael
Format: Article
Language:English
Subjects:
Adult
Algorithms
Animals
Brain Mapping - methods
Cluster Analysis
clustering
Female
Frontal Lobe - anatomy & histology
Frontal Lobe - physiology
functional magnetic resonance imaging
Humans
Image Processing, Computer-Assisted
inferior frontal gyrus
Language
Macaca
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net - anatomy & histology
Nerve Net - physiology
Neural Pathways - anatomy & histology
Neural Pathways - physiology
Primates
resting state
Temporal Lobe - anatomy & histology
Temporal Lobe - physiology
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Summary:Brodmann areas 6, 44 and 45 in the ventrolateral frontal cortex of the left hemisphere of the human brain constitute the anterior language production zone. The anatomical connectivity of these areas with parietal and temporal cortical regions was recently examined in an autoradiographic tract‐tracing study in the macaque monkey. Studies suggest strong correspondence between human resting state functional connectivity (RSFC) based on functional magnetic resonance imaging data and experimentally demonstrated anatomical connections in non‐human primates. Accordingly, we hypothesized that areas 6, 44 and 45 of the human brain would exhibit patterns of RSFC consistent with patterns of anatomical connectivity observed in the macaque. In a primary analysis, we examined the RSFC associated with regions‐of‐interest placed in ventrolateral frontal areas 6, 44 and 45, on the basis of local sulcal and gyral anatomy. We validated the results of the primary hypothesis‐driven analysis with a data‐driven partitioning of ventrolateral frontal cortex into regions exhibiting distinct RSFC patterns, using a spectral clustering algorithm. The RSFC of ventrolateral frontal areas 6, 44 and 45 was consistent with patterns of anatomical connectivity shown in the macaque. We observed a striking dissociation between RSFC for the ventral part of area 6 that is involved in orofacial motor control and RSFC associated with Broca’s region (areas 44 and 45). These findings indicate rich and differential RSFC patterns for the ventrolateral frontal areas controlling language production, consistent with known anatomical connectivity in the macaque brain, and suggest conservation of connectivity during the evolution of the primate brain.
ISSN:0953-816X
1460-9568
DOI:10.1111/j.1460-9568.2010.07279.x