Abnormal Urinary Kallikrein in Hypertension Is Not Related To Aldosterone Or Plasma Renin Activity

SUMMARY The relationships between urinary kallikrein (Uk.,), and plasma renin activity (PRA), urinary aldosterone (U«ldo), Na balance, SK, and renal function were studied in essential hypertensives (EHT) and normals. Utal was measured by a radiochemical esterolytic assay. We studied 18 white patient...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1980-11, Vol.2 (6), p.787-793
Main Authors: LAWTON, WILLIAM J, FITZ, ANNETTE E
Format: Article
Language:English
Subjects:
Adult
Aldosterone - metabolism
Diet, Sodium-Restricted
Female
Humans
Hyperaldosteronism - physiopathology
Hypertension - physiopathology
Kallikreins - urine
Kidney - physiopathology
Male
Renin - blood
Sodium - administration & dosage
Sodium - metabolism
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Summary:SUMMARY The relationships between urinary kallikrein (Uk.,), and plasma renin activity (PRA), urinary aldosterone (U«ldo), Na balance, SK, and renal function were studied in essential hypertensives (EHT) and normals. Utal was measured by a radiochemical esterolytic assay. We studied 18 white patients with EHT (15 men, 3 women) ages 31.6 ± 2.1 (SEM) yrs, BP 138 ± 2/95 ± 2 mm Hg. and 12 white normals (NLS) (7 men, 5 women) ages 30.2 ± 2 3 yrs, BP 112 ± 4/71 ± 2 mm Hg. All received a 5-day diet of 400 raEq Na, 80 mEq K/day, and 5 days of 10 mEq Na, 80 mEq K/day. All achieved Na balance by Day 5. On Day 5 of the low Na diet, 24 hr. U$, in EHT was 15.8 ± 2.4 (esterase units/24 hr) rs NLS, 17.0 ± 2.8. PRA was the same in EHT and NLS, but U.ldo was higher in NLS. (Day 5, low Na, EHT, U«ld0 − 29.4 ± 33 Mg/24h. vs NLS 41.8 ± 4.7, p< 0.02). Analysis of individuals showed that all NLS increased U after salt restriction, while 3 EHT decreased U$j after salt restriction. This abnormal response In EHT was not related to abnormalities in Undo, PRA, Na balance, SK, or creatinine clearance. In 3 EHT with low-renln EHT, toe UkaJresponse was normal. In two of four patients with primary aldosteronism, Ut., was normal despite increasedU.ido- The Urn response to salt restriction is abnormal in some EHT, unrelated to U$ao or PRA, suggesting either a primary defect in U$, and/or the presence of other factors modulating U$, in EHT.
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.2.6.787