Analytical radiography for planar radiographic images implemented with a multi-modal system

Abstract A radiographic system is optimized for the contrast inherent to small animals and is developed for a multi-modal imaging system devised for in-vivo studies. The range of X-ray energies utilized (generally considered “soft X-rays”) enables enhanced spatial resolution and superior contrast fo...

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Bibliographic Details
Published in:Computer methods and programs in biomedicine 2010-07, Vol.99 (1), p.88-97
Main Authors: Vizard, Douglas L, Wood, Douglas O, Papineni, Rao V.L, Feke, Gilbert D, Orton, Sean P, McLaughlin, William E
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Bone and Bones - diagnostic imaging
Bone Density
Bone symmetry
Imaging
In vivo
Internal Medicine
Medical sciences
Mice
Mouse
Multi-modal
Other
Radiographic Image Interpretation, Computer-Assisted - methods
Radiography
Radiology
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Soft X-ray
Technology. Biomaterials. Equipments. Material. Instrumentation
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Summary:Abstract A radiographic system is optimized for the contrast inherent to small animals and is developed for a multi-modal imaging system devised for in-vivo studies. The range of X-ray energies utilized (generally considered “soft X-rays”) enables enhanced spatial resolution and superior contrast for detailed study of the mouse anatomy and smaller specimens. Despite the difficulties presented by the complicated energy spectrum of soft X-rays, relevant system calibrations for bone measures are described in detail and applied to the mouse. Further, long-bone symmetry modeling using a cylindrical projection is applied to the planar density image, providing convenient bone density estimates that are consistent with other methodologies.
ISSN:0169-2607
1872-7565
DOI:10.1016/j.cmpb.2010.01.003