beta-Thalassemia trait and hyperbilirubinemia in G-6-PD deficient newborn infants

Hb A2 was determined in 50 subjects with erythrocyte G-6-PD deficiency who presented with hyperbilirubinemia in the neonatal period and in 100 non-hyperbilirubinemic G-6-PD deficient newborn infants, at the age of 12 months or more. Six subjects in the first group and 13 in the second were found to...

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Bibliographic Details
Published in:European journal of pediatrics 1980-08, Vol.134 (2), p.119-120
Main Authors: Meloni, T, Erre, S, Gallisai, D, Cutillo, S
Format: Article
Language:English
Subjects:
Glucosephosphate Dehydrogenase Deficiency - blood
Glucosephosphate Dehydrogenase Deficiency - complications
Hemoglobin A2 - analysis
Heterozygote
Humans
Infant
Infant, Newborn
Jaundice, Neonatal - blood
Jaundice, Neonatal - complications
Male
Thalassemia - genetics
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Summary:Hb A2 was determined in 50 subjects with erythrocyte G-6-PD deficiency who presented with hyperbilirubinemia in the neonatal period and in 100 non-hyperbilirubinemic G-6-PD deficient newborn infants, at the age of 12 months or more. Six subjects in the first group and 13 in the second were found to be carriers of the beta-thalassemia trait. Statistical analysis of the data did not show any significant difference between the two groups. It seems that the beta-thalassemia trait does not provide any protection against neonatal hyperbilirubinemia associated with G-6-PD deficiency.
ISSN:0340-6199
1432-1076
DOI:10.1007/BF01846028