Role of growth hormone in experimental phosphorus deprivation in the rat

The demands of growth are known to exacerbate the effect of phosphorus deprivation (PD). We examined whether changes associated with PD could be prevented in young rats in which growth and growth hormone (GH) were eliminated by hypophysectomy (HPX) and whether PD in normal intact rats (INT) was asso...

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Published in:Calcified tissue international 1980-01, Vol.32 (2), p.105-112
Main Authors: Lee, D B, Brautbar, N, Walling, M W, Silis, V, Carlson, H E, Grindeland, R E, Coburn, J W, Kleeman, C R
Format: Article
Language:English
Subjects:
Animals
Biological Assay
Body Weight
Calcium - metabolism
Diet
Duodenum - metabolism
Growth Hormone - physiology
Hypophysectomy
Intestinal Absorption
Male
Phosphates - blood
Phosphates - metabolism
Phosphorus - deficiency
Pituitary Gland - physiology
Rats
Space life sciences
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Summary:The demands of growth are known to exacerbate the effect of phosphorus deprivation (PD). We examined whether changes associated with PD could be prevented in young rats in which growth and growth hormone (GH) were eliminated by hypophysectomy (HPX) and whether PD in normal intact rats (INT) was associated with increased secretion of GH. INT or thyroxine- and ACTH-replaced HPX rats were fed one of the three diets: 0.31% P (NP); 0.027% P (LP), and 0.31% P, pair-fed with LP-mates (NP-PF). The results indicate that HPX did not qualitatively alter several physiologic responses to PD: (a) serum and urinary phosphorus (P) decreased and urinary calcium (Ca) increased; (b) net intestinal Ca retention fell and duodenal sac uptake of 45Ca rose; and (c) external P balance was restored and duodenal sac uptake of 32P-phosphate increased. Only the hypercalcemia seen in INT, LP rats was prevented by HPX. In INT rats serum immunoassayable GH levels, measured in single samples, were not different between different dietary groups while pituitary bioassayable GH was reduced in both LP and NP-PF rats when compared to the NP rats. Thus, except for hypercalcemia, the physiologic responses associated with PD are not prevented by the elimination of growth and GH, and the development of these responses in INT rats was not associated with a consistent or specific alteration in GH secretion.
ISSN:0171-967X
1432-0827
DOI:10.1007/BF02408529