Radioimmunodetection of gastrointestinal neoplasms with antibodies to carcinoembryonic antigen

Primary and secondary gastrointestinal tumors have been identified using sheep immunoglobulin G antibody to carcinoembryonic antigen radiolabeled with 131I. 99mTc-pertechnetate and 99mTc-human serum albumin were used to identify tissue spaces and blood pool and to facilitate external substraction im...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1980-08, Vol.40 (8 Pt 2), p.2993-2996
Main Authors: Hine, K R, Bradwell, A R, Reeder, T A, Drolc, Z, Dykes, P W
Format: Article
Language:English
Subjects:
Antibodies, Neoplasm - administration & dosage
Carcinoembryonic Antigen - analysis
Carcinoembryonic Antigen - immunology
Gastrointestinal Neoplasms - diagnostic imaging
Gastrointestinal Neoplasms - immunology
Humans
Immunoglobulin G - administration & dosage
Iodine Radioisotopes
Radionuclide Imaging - methods
Technetium
Time Factors
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Summary:Primary and secondary gastrointestinal tumors have been identified using sheep immunoglobulin G antibody to carcinoembryonic antigen radiolabeled with 131I. 99mTc-pertechnetate and 99mTc-human serum albumin were used to identify tissue spaces and blood pool and to facilitate external substraction imaging. In 13 patients with tumors, 4 of 5 primary sites and 8 of 11 secondary sites were successfully demonstrated. Two patients with benign disease had negative scans. Comparison with conventional methods of scanning showed good correlation.
ISSN:0008-5472
1538-7445