Hla antigens and rheumatoid arthritis association between hla‐drw4 positivity and igm rheumatoid factor production

Serologic HLA typing was carried out on 33 seropositive and 15 seronegative patients with rheumatoid arthritis (RA). Association with the DRw4 antigen was found only in seropositive RA (61%, compared with 27% in normal controls; P < 0.05, Fisher's exact test), whereas the antigen had a norma...

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Bibliographic Details
Published in:Arthritis and rheumatism 1980-03, Vol.23 (3), p.309-313
Main Authors: Dobloug, Jan H., Førre, Øystein, Kåss, Erik, Thorsby, Erik
Format: Article
Language:English
Subjects:
Adult
Aged
Arthritis, Rheumatoid - immunology
Complement System Proteins - biosynthesis
Female
HLA Antigens - analysis
Humans
Immunoglobulin M - immunology
Immunoglobulins - biosynthesis
Male
Middle Aged
Rheumatoid Factor - biosynthesis
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Summary:Serologic HLA typing was carried out on 33 seropositive and 15 seronegative patients with rheumatoid arthritis (RA). Association with the DRw4 antigen was found only in seropositive RA (61%, compared with 27% in normal controls; P < 0.05, Fisher's exact test), whereas the antigen had a normal frequency in seronegative RA patients (27%). The serum concentrations of IgM and IgE immunoglobulins were significantly higher in seropositive than in seronegative RA patients (P < 0.01, Mann‐Whitney test), whereas the concentrations of the other immunoglobulin classes and of the complement factors C3 and C4 did not show any significant differences.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780230307