Adenosine-Triphosphate-Binding Cassette Transporter-1 Trafficking and Function

Mutations in the adenosine-triphosphate-binding cassette transporter-1 (ABCA1) lead to Tangier disease, a genetic disorder characterized by an almost complete absence of plasma high-density lipoprotein cholesterol. Although the importance of ABCA1 localization to its cholesterol efflux function has...

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Bibliographic Details
Published in:Trends in cardiovascular medicine 2010-02, Vol.20 (2), p.41-49
Main Authors: Kang, Martin H, Singaraja, Roshni, Hayden, Michael R
Format: Article
Language:English
Subjects:
Animals
Apolipoprotein A-I - metabolism
Atherosclerosis
ATP Binding Cassette Transporter 1
ATP-Binding Cassette Transporters - genetics
ATP-Binding Cassette Transporters - metabolism
Biological Transport
Brain
Cardiovascular
Cell Membrane - metabolism
Cholesterol
Cholesterol - metabolism
Cystic Fibrosis Transmembrane Conductance Regulator - metabolism
Endoplasmic Reticulum - metabolism
Gene Expression
Genes
Golgi Apparatus - metabolism
Homeostasis
Humans
Lipoproteins
Lipoproteins, HDL - metabolism
Medical research
Mice
Mutation
Plasma
Protein folding
Protein Processing, Post-Translational - physiology
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Summary:Mutations in the adenosine-triphosphate-binding cassette transporter-1 (ABCA1) lead to Tangier disease, a genetic disorder characterized by an almost complete absence of plasma high-density lipoprotein cholesterol. Although the importance of ABCA1 localization to its cholesterol efflux function has been extensively characterized, the cellular itinerary of ABCA1 leading to the plasma membrane is not fully elucidated. This review will summarize the current knowledge of ABCA1 trafficking and its relationship to function. Understanding these crucial processes provides potential novel therapeutic targets to regulate high-density lipoprotein biogenesis through influencing pathways of ABCA1 trafficking.
ISSN:1050-1738
1873-2615
DOI:10.1016/j.tcm.2010.03.006