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Manipulation of dendritic cell function by viruses

Viruses manipulate the function of dendritic cells (DCs) to enhance their entry, spread, survival and transmission. This review summarises recently published work identifying how viruses alter the expression of receptors, antiviral molecules, disrupt signalling pathways, subvert trafficking pathways...

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Bibliographic Details
Published in:Current opinion in microbiology 2010-08, Vol.13 (4), p.524-529
Main Authors: Cunningham, Anthony L, Donaghy, Heather, Harman, Andrew N, Kim, Min, Turville, Stuart G
Format: Article
Language:English
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Summary:Viruses manipulate the function of dendritic cells (DCs) to enhance their entry, spread, survival and transmission. This review summarises recently published work identifying how viruses alter the expression of receptors, antiviral molecules, disrupt signalling pathways, subvert trafficking pathways and even affect DC function via interactions with second or third cell types. Different viruses such as human immunodeficiency virus (HIV) and herpes viruses may have widely divergent and even opposite effects on DC function, determined by the need for transfer to a primary target cell, replication within the DC or various immunoevasive mechanisms.
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2010.06.002