Approaches to the Study of Drug-Induced Liver Injury

Retrospective studies of administrative databases have led to highly variable estimates of the incidence and natural history of drug‐induced liver injury (DILI) and the agents implicated. In contrast, prospective multicenter registry studies allow for more accurate phenotyping of individual patients...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2010-09, Vol.88 (3), p.416-419
Main Author: Fontana, R J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers, Pharmacological - metabolism
Chemical and Drug Induced Liver Injury - epidemiology
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - physiopathology
Databases, Factual
Drug-Related Side Effects and Adverse Reactions
Humans
Incidence
Medical sciences
Pharmacology. Drug treatments
Phenotype
Registries
Research Design
Severity of Illness Index
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Summary:Retrospective studies of administrative databases have led to highly variable estimates of the incidence and natural history of drug‐induced liver injury (DILI) and the agents implicated. In contrast, prospective multicenter registry studies allow for more accurate phenotyping of individual patients with DILI, as well as for collection of biological samples for mechanistic studies. In addition to improved diagnostic and prognostic biomarkers, standardized causality assessment tools are needed, as well as population‐based studies that represent the full spectrum of disease severity. This would facilitate further research into the pathogenesis of DILI, leading ultimately to the prevention of this condition. Clinical Pharmacology & Therapeutics (2010) 88 3, 416–419. doi: 10.1038/clpt.2010.100
ISSN:0009-9236
1532-6535
DOI:10.1038/clpt.2010.100