Silver triflate and N-heterocyclic carbene co-catalyzed reaction of N'-(2-alkynylbenzylidene)hydrazide, methanol with alpha,beta-unsaturated aldehyde

A highly efficient silver triflate and N-heterocyclic carbene co-catalyzed three-component reaction of N'-(2-alkynylbenzylidene)hydrazide, methanol with alpha,beta-unsaturated aldehyde is described, which gives rise to the 2-amino-1,2-dihydroisoquinolines in good yield.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2010-09, Vol.46 (34), p.6356-6358
Main Authors: Chen, Zhiyuan, Yu, Xingxin, Wu, Jie
Format: Article
Language:English
Subjects:
Aldehydes - chemistry
Azides - chemistry
Catalysis
Heterocyclic Compounds - chemistry
Isoquinolines - chemical synthesis
Isoquinolines - chemistry
Mesylates - chemistry
Methane - analogs & derivatives
Methane - chemistry
Methanol - chemistry
Molecular Structure
Stereoisomerism
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Description
Summary:A highly efficient silver triflate and N-heterocyclic carbene co-catalyzed three-component reaction of N'-(2-alkynylbenzylidene)hydrazide, methanol with alpha,beta-unsaturated aldehyde is described, which gives rise to the 2-amino-1,2-dihydroisoquinolines in good yield.
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc01207f