Insight into the patterns of cerebrospinal fluid flow in the human ventricular system using MR velocity mapping

The patterns of cerebrospinal fluid (CSF) flow within the human ventricular system are still not fully understood in all their complexity. Knowledge is based on either the interpretation of CSF flow curves or computational simulations. Both approaches only provide an incomplete insight into the spat...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2010-05, Vol.51 (1), p.42-52
Main Authors: Stadlbauer, Andreas, Salomonowitz, Erich, van der Riet, Wilma, Buchfelder, Michael, Ganslandt, Oliver
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aging - physiology
Alzheimer's disease
Brain research
Cerebral Ventricles - physiology
Cerebrospinal fluid
Cerebrospinal Fluid - physiology
Female
Flow pattern
Fourth Ventricle - physiology
Heart - physiology
Humans
Hydrocephalus
Imaging, Three-Dimensional - methods
Lateral Ventricles - physiology
Magnetic Resonance Imaging - methods
Magnetic resonance velocity mapping
Male
Middle Aged
NMR
Nuclear magnetic resonance
Periodicity
Standard deviation
Time Factors
Ventricular system
Young Adult
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Summary:The patterns of cerebrospinal fluid (CSF) flow within the human ventricular system are still not fully understood in all their complexity. Knowledge is based on either the interpretation of CSF flow curves or computational simulations. Both approaches only provide an incomplete insight into the spatial and temporal dynamics of CSF flow. Time-resolved three-dimensional magnetic resonance velocity mapping has previously been used to investigate normal and pathologic blood flow patterns in the human vascular system. Here we used this technique to study the spatial and temporal dynamics of CSF flow in the ventricular system of 40 normal volunteers. Classification of the patterns of CSF flow based on calculation of three-dimensional particle path lines over the cardiac cycle revealed one uniform flow pattern for the lateral ventricles, three categories for the third and two categories for the fourth ventricle. We found no significant aging effects on either the presence of a specific CSF flow pattern or on CSF flow velocities. Our results provide the first detailed demonstration of the patterns of CSF flow within the human ventricular system.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2010.01.110