A 90 days oral toxicity of imidacloprid in female rats: Morphological, biochemical and histopathological evaluations

A 90 days oral toxicity study of imidacloprid was conducted in female rats with doses of 0, 5, 10, 20 mg/kg/day. Decrease in the body weight gain was observed at 20 mg/kg/day and at necropsy the relative body weights of liver, kidney and adrenal was also significantly increased at this dose level. N...

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Bibliographic Details
Published in:Food and chemical toxicology 2010-05, Vol.48 (5), p.1185-1190
Main Authors: Bhardwaj, Shipra, Srivastava, M.K., Kapoor, Upasana, Srivastava, L.P.
Format: Article
Language:English
Subjects:
90 days oral toxicity
Acetylcholinesterase - blood
animal morphology
Animals
biochemical compounds
Biological and medical sciences
Body Weight - drug effects
Brain
Brain - drug effects
Brain - enzymology
Brain - pathology
Cholinesterase Inhibitors - pharmacology
dietary exposure
dose response
Dose-Response Relationship, Drug
Eating - drug effects
Female
Female rats
Females
Hematologic Tests
histopathology
Imidacloprid
Imidazoles - toxicity
Insecticides - toxicity
Kidney - drug effects
Kidney - pathology
Kidneys
Liver
Liver - drug effects
Liver - enzymology
Liver - pathology
Medical sciences
Motor Activity - drug effects
Neonicotinoids
Nitro Compounds - toxicity
No observed effect level (NOEL)
No-Observed-Adverse-Effect Level
oral administration
Organ Size - drug effects
Pesticides, fertilizers and other agrochemicals toxicology
Purkinje Cells - drug effects
Purkinje Cells - pathology
Rats
Rats, Wistar
Serums
Toxicity
toxicity testing
Toxicity Tests
Toxicology
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Summary:A 90 days oral toxicity study of imidacloprid was conducted in female rats with doses of 0, 5, 10, 20 mg/kg/day. Decrease in the body weight gain was observed at 20 mg/kg/day and at necropsy the relative body weights of liver, kidney and adrenal was also significantly increased at this dose level. No mortality occurred during treatment period while food intake was reduced at high dose level. In clinical chemistry parameters high dose of imidacloprid has caused significant elevation of serum GOT, GPT, glucose and BUN and decreased the activity of AChE in serum and brain. The spontaneous locomotor activity was also decreased at highest dose exposure where as there were no significant changes in hematological and urine parameters. The brain, liver and kidney of rats exposed with high dose of imidacloprid had showed mild pathological changes. Based on the morphological, biochemical, hematological and neuropathological studies it is evident that imidacloprid has not produced any significant effects at 5 and 10 mg/kg/day doses but induced toxicological effects at 20 mg/kg/day to female rats. Hence, 10 mg/kg/day dose may be considered as no observed effect level (NOEL) for female rats.
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2010.02.009