Simvastatin enhances bone formation around titanium implants in rat tibiae

Summary  Statins are cholesterol‐lowering drugs that have been reported to promote bone formation. The purpose of this study was to investigate the effect of simvastatin on the enhancement of bone formation around titanium implants. Thirty‐week‐old female rats received pure titanium implants in both...

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Bibliographic Details
Published in:Journal of oral rehabilitation 2010-02, Vol.37 (2), p.123-130
Main Authors: AYUKAWA, Y., OGINO, Y., MORIYAMA, Y., ATSUTA, I., JINNO, Y., KIHARA, M., TSUKIYAMA, Y., KOYANO, K.
Format: Article
Language:English
Subjects:
Acid Phosphatase - blood
Animals
Anticholesteremic Agents - administration & dosage
Anticholesteremic Agents - pharmacology
Biomarkers - blood
bone
Bone Density - drug effects
Bone Marrow - drug effects
Bone Marrow - pathology
Bone Resorption - blood
Colorimetry
Dental Implants
Dental Materials - chemistry
Dentistry
Female
histomorphometry
Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
Injections, Intraperitoneal
Isoenzymes - blood
Osseointegration - physiology
Osteocalcin - blood
Osteogenesis - drug effects
rat
Rats
simvastatin
Simvastatin - administration & dosage
Simvastatin - pharmacology
Tartrate-Resistant Acid Phosphatase
Tibia - drug effects
Tibia - pathology
Time Factors
Titanium - chemistry
titanium implant
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Summary:Summary  Statins are cholesterol‐lowering drugs that have been reported to promote bone formation. The purpose of this study was to investigate the effect of simvastatin on the enhancement of bone formation around titanium implants. Thirty‐week‐old female rats received pure titanium implants in both tibiae. The animals were intra‐peritoneally administered 0, 0·125, 1, 5 or 10 mg kg−1 of simvastatin daily. After 30 days, the animals were sacrificed, and specimens were prepared. The bone contact ratio of the implant, bone density in the medullary canal and percentage of cortical bone were obtained. Markers for bone turnover were also measured using sera collected at the time of euthanasia. In the medullary canal, a scanty amount of bone was observed in the 0, 0·125 and 1 mg kg−1 groups. In contrast, in both the 5 and 10 mg kg−1 groups, thicker bone trabeculae were abundant. Histometric observations showed that the bone contact ratio and the bone density of both groups were significantly greater than those of the other groups (anova, P 
ISSN:0305-182X
1365-2842
DOI:10.1111/j.1365-2842.2009.02011.x