Adrenocorticotropin acutely increases adrenal polyphosphoinositides

After adrenocorticotropin (ACTH) treatment for 15 min, adrenal levels of diphosphoinositide and triphosphoinositide appear to increase severalfold. Several other adrenal phospholipids are not appreciably affected by such treatment. Rapid changes in polyphosphoinositides may play a role in hormonal m...

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Bibliographic Details
Published in:The Journal of biological chemistry 1979-08, Vol.254 (15), p.6842-6844
Main Authors: Farese, R V, Sabir, A M, Vandor, S L
Format: Article
Language:English
Subjects:
Adrenal Glands - drug effects
Adrenal Glands - metabolism
Adrenocorticotropic Hormone - pharmacology
Animals
Chromatography, Thin Layer
Male
Phosphatidylinositols - biosynthesis
Phospholipids - metabolism
Rats
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Summary:After adrenocorticotropin (ACTH) treatment for 15 min, adrenal levels of diphosphoinositide and triphosphoinositide appear to increase severalfold. Several other adrenal phospholipids are not appreciably affected by such treatment. Rapid changes in polyphosphoinositides may play a role in hormonal modulation of membrane-associated metabolic events.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(18)50247-7