Preliminary genome-wide association study of bipolar disorder in the Japanese population

Recent progress in genotyping technology and the development of public databases has enabled large‐scale genome‐wide association tests with diseases. We performed a two‐stage genome‐wide association study (GWAS) of bipolar disorder (BD) in Japanese cohorts. First we used Affymetrix 100K GeneChip arr...

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Bibliographic Details
Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2009-12, Vol.150B (8), p.1110-1117
Main Authors: Hattori, Eiji, Toyota, Tomoko, Ishitsuka, Yuichi, Iwayama, Yoshimi, Yamada, Kazuo, Ujike, Hiroshi, Morita, Yukitaka, Kodama, Masafumi, Nakata, Kenji, Minabe, Yoshio, Nakamura, Kazuhiko, Iwata, Yasuhide, Takei, Nori, Mori, Norio, Naitoh, Hiroshi, Yamanouchi, Yoshio, Iwata, Nakao, Ozaki, Norio, Kato, Tadafumi, Nishikawa, Toru, Kashiwa, Atsushi, Suzuki, Mika, Shioe, Kunihiko, Shinohara, Manabu, Hirano, Masami, Nanko, Shinichiro, Akahane, Akihisa, Ueno, Mikako, Kaneko, Naoshi, Watanabe, Yuichiro, Someya, Toshiyuki, Hashimoto, Kenji, Iyo, Masaomi, Itokawa, Masanari, Arai, Makoto, Nankai, Masahiro, Inada, Toshiya, Yoshida, Sumiko, Kunugi, Hiroshi, Nakamura, Michiko, Iijima, Yoshimi, Okazaki, Yuji, Higuchi, Teruhiko, Yoshikawa, Takeo
Format: Article
Language:English
Subjects:
Adult
Affymetrix 100K
Aged
Asian Continental Ancestry Group - genetics
Bipolar Disorder - epidemiology
Bipolar Disorder - genetics
Case-Control Studies
Female
Genetic Markers
Genome-Wide Association Study - methods
Humans
Illumina Beadarray
Japan - epidemiology
Male
Middle Aged
Oligonucleotide Array Sequence Analysis
Pilot Projects
PLXNA2
Principal Component Analysis
principal components analysis
SNAP25
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Summary:Recent progress in genotyping technology and the development of public databases has enabled large‐scale genome‐wide association tests with diseases. We performed a two‐stage genome‐wide association study (GWAS) of bipolar disorder (BD) in Japanese cohorts. First we used Affymetrix 100K GeneChip arrays in the analysis of 107 cases with bipolar I disorder and 107 controls, and selected markers that were nominally significant (P 
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.30941