Glucose influence on the production of T-2 toxin by Fusarium sporotrichioides

Toxigenic isolate of Fusarium sporotrichioides was tested for the T-2 toxin production on PDA plates during 10 days under various glucose concentrations. T-2 toxin was determined by LC–MS and confirmed with LC–MS/MS. This analytical method has been applied, for the first time, to an extensive study...

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Bibliographic Details
Published in:Toxicon (Oxford) 2010-06, Vol.55 (6), p.1157-1161
Main Authors: Blesa, J., Meca, G., Rubert, J., Soriano, J.M., Ritieni, A., Mañes, J.
Format: Article
Language:English
Subjects:
Animal poisons toxicology. Antivenoms
Biological and medical sciences
Chromatography, High Pressure Liquid
Culture Media, Conditioned - chemistry
Fusarium - drug effects
Fusarium - metabolism
Fusarium sporotrichioides
Glucose
Glucose - pharmacology
LC–MS
Medical sciences
PDA
Plant poisons toxicology
T-2 toxin
T-2 Toxin - analysis
T-2 Toxin - biosynthesis
Tandem Mass Spectrometry
Toxicology
Trichothecenes
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Summary:Toxigenic isolate of Fusarium sporotrichioides was tested for the T-2 toxin production on PDA plates during 10 days under various glucose concentrations. T-2 toxin was determined by LC–MS and confirmed with LC–MS/MS. This analytical method has been applied, for the first time, to an extensive study of T-2 accumulation. Results showed that the production of this mycotoxin is directly correlated to the concentration of glucose present in the medium. Concentrations of T-2 toxin produced by the strain of F. sporotrichioides ranged from 0 to 1.45 mg/kg. The better T-2 production was evidenced in the fermentation operated with 20% of glucose.
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2010.01.005