Subfertile men with constitutive chromosome abnormalities do not necessarily refrain from intracytoplasmic sperm injection treatment: a follow-up study on 75 Dutch patients

A follow-up study was performed to investigate the impact of the detection of a chromosome abnormality in infertile men who are candidates for intracytoplasmic sperm injection (ICSI) treatment. In this collaborative study between clinical genetics centres and fertility clinics in the Netherlands, 75...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1999-02, Vol.14 (2), p.318-320
Main Authors: Giltay, J.C., Kastrop, P.M.M., Tuerlings, J.H.A.M., Kremer, JA.M., Tiemessen, C.H.J., Gerssen-Schoorl, K.B.J., van derVeen, F., deVries, J., Hordijk, R., Hamers, G.J.H., Hansson, K., van der Blij-Philipsen, M., Govaerts, L.C.P., Pieters, M.H.E.C., Madan, K., Scheres, J.M.J.C.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Chromosome Aberrations - diagnosis
Chromosome Aberrations - physiopathology
chromosome abnormality
Chromosome Disorders
Cytoplasm - physiology
Female
follow-up
Follow-Up Studies
Gynecology. Andrology. Obstetrics
Humans
Infertility, Male - genetics
intracytoplasmic sperm injection (ICSI)
Karyotyping
Male
Male genital diseases
male infertility
Medical sciences
Micromanipulation
Non tumoral diseases
oligoasthenoteratozoospermia (OAT)
Pregnancy
Pregnancy Rate
Prenatal Diagnosis
Reference Values
Spermatozoa - physiology
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Summary:A follow-up study was performed to investigate the impact of the detection of a chromosome abnormality in infertile men who are candidates for intracytoplasmic sperm injection (ICSI) treatment. In this collaborative study between clinical genetics centres and fertility clinics in the Netherlands, 75 ICSI couples of which the male partners had a chromosome abnormality were included. All couples were extensively counselled on the risk of having a chromosomally unbalanced child. Forty-two out of 75 couples chose to proceed with the ICSI treatment. So far, treatment has resulted in a pregnancy in 11 cases. Four of them opted to have invasive prenatal diagnosis. Despite the genetic risks related to a chromosome abnormality in infertile men, a small majority (56%) of the couples did not refrain from the ICSI treatment.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/14.2.318