Effects of immunosuppressant FK-506 on tooth movement

To cite this article: 
Santos RL, de Farias MLF, de Mendonça LMC, Gonçalves RT, Martins MA, de Souza MMG:
Effects of immunosuppressant FK‐506 on tooth movement
Orthod Craniofac Res 2010;13:153–161 Structured Authors –  Santos RL, de Farias MLF, de Mendonça LMC, Gonçalves RT, Martins MA, de Souza MMG...

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Published in:Orthodontics & craniofacial research 2010-08, Vol.13 (3), p.153-161
Main Authors: Santos, RL, De Farias, MLF, De Mendonça, LMC, Gonçalves, RT, Martins, MA, De Souza, MMG
Format: Article
Language:English
Subjects:
Alveolar Process - cytology
Animals
Apoptosis
bone
Bone Density - drug effects
Bone Remodeling - drug effects
Bone Resorption
Dental Stress Analysis
Dentistry
immunosuppressant
Immunosuppressive Agents - pharmacology
Leukocyte Count
Male
orthodontics
Osteoclasts - drug effects
Random Allocation
Rats
Rats, Wistar
Tacrolimus - pharmacology
tooth movement
Tooth Movement Techniques
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Summary:To cite this article: 
Santos RL, de Farias MLF, de Mendonça LMC, Gonçalves RT, Martins MA, de Souza MMG:
Effects of immunosuppressant FK‐506 on tooth movement
Orthod Craniofac Res 2010;13:153–161 Structured Authors –  Santos RL, de Farias MLF, de Mendonça LMC, Gonçalves RT, Martins MA, de Souza MMG Objective –  To test the hypothesis that immunosuppressant tacrolimus treatment can interfere with bone turnover and rate of tooth movement. Material and Methods –  One‐hundred twenty Wistar male rats were divided into four groups: Group 1 (rats subjected to orthodontic movement plus treatment with saline solution vehicle), Group 2 (rats subjected to orthodontic movement plus treatment with FK506), Group 3 (rats treated with FK506 only), and Group 4 (rats treated with saline solution vehicle). The maxillary incisors were laterally moved with a reciprocal load of 35 cN. The dosage of FK506 was 2 mg/kg/day. Howship’s lacunae, osteoclasts, and macrophages were counted. Results –  Tooth movement was found to be greater in Group 1 than in Group 2 for all time periods (on days 3, 7, and 14), although a significant difference was observed only on days 7 and 14 (p 
ISSN:1601-6335
1601-6343
DOI:10.1111/j.1601-6343.2010.01489.x