Combined type‐1 plasminogen activator inhibitor and NOD2/CARD15 genotyping predicts complicated Crohn's disease behaviour

Summary Background NOD2/CARD15 gene variants have not been universally associated with stricturing behaviour in Crohn's disease. Other behaviour modifying genes could explain these results. Aim To study the combined influence of NOD2/CARD15 variants and 4G/4G genotype of type‐1 plasminogen acti...

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Published in:Alimentary pharmacology & therapeutics 2007-02, Vol.25 (4), p.429-440
Main Authors: ALVAREZ‐LOBOS, M., AROSTEGUI, J. I., SANS, M., TASSIES, D., PIU, J., REVERTER, J. C., PIQUE, J. M., YAGÜE, J., PANÉS, J.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Crohn Disease - genetics
Digestive system
Female
Gastroenterology. Liver. Pancreas. Abdomen
Genetic Predisposition to Disease - genetics
Genotype
Humans
Male
Medical sciences
Middle Aged
Nod2 Signaling Adaptor Protein - genetics
Other diseases. Semiology
Pharmacology. Drug treatments
Plasminogen Activator Inhibitor 1 - genetics
Polymorphism, Genetic
Prospective Studies
Risk Factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:Summary Background NOD2/CARD15 gene variants have not been universally associated with stricturing behaviour in Crohn's disease. Other behaviour modifying genes could explain these results. Aim To study the combined influence of NOD2/CARD15 variants and 4G/4G genotype of type‐1 plasminogen activator inhibitor (PAI‐1) gene on Crohn's disease behaviour. Methods One hundred and seventy Crohn's disease patients were studied prospectively, with a mean follow‐up of 7± 6 years. Disease behaviour was registered by using two criteria: the Vienna classification and a non‐hierarchical classification based on the behavioural Vienna categories. Results In the multivariate analysis for stricturing behaviour according to the Vienna categories, only absence of colonic disease (OR, 4.0; 95% CI: 1.49–11.1; P = 0.006) was an independent predictive factor. However, in the multivariate analysis for stricturing disease applying a non‐hierarchical criteria, ileal disease (OR, 4.19; 95% CI: 1.30–13.5; P = 0.01), and carrying both NOD2/CARD15 variants and the 4G/4G PAI‐1 genotype (OR, 5.02; 95% CI: 1.44–17.48; P = 0.01) were independent predictive factors. In the multivariate analysis for penetrating behaviour, the 4G/4G PAI‐1 (OR, 3.10; 95% CI: 1.54–6.23; P = 0.001) and male sex (OR, 2.44; 95% CI: 1.30–4.60; P = 0.005) were independent predictive factors irrespective of criteria applied. Conclusions Combined PAI‐1 and NOD2/CARD15 genotyping predict complicated Crohn's disease. Patients with these variants could benefit from early interventions.
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2006.03208.x