Reproductive and developmental toxicity screening study of 2,4-dinitrophenol in rats

Rats were treated by gavage once daily with 2,4-dinitrophenol (DNP) at 0 (control), 3, 10, or 30 mg/kg bw. Males were dosed for 46 days, beginning 14 days before mating, and females were dosed for 40-47 days, from 14 days before mating to day 3 of lactation. No deaths were observed in males and fema...

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Published in:Environmental toxicology 2009-02, Vol.24 (1), p.74-81
Main Authors: Takahashi, Mika, Sunaga, Masao, Hirata-Koizumi, Mutsuko, Hirose, Akihiko, Kamata, Eiichi, Ema, Makoto
Format: Article
Language:English
Subjects:
2,4-Dinitrophenol - toxicity
2,4‐dinitrophenol
4-dinitrophenol
Abnormalities, Drug-Induced
Animal, plant and microbial ecology
Animals
Animals, Newborn - growth & development
Applied ecology
Biological and medical sciences
Body Weight
Ecotoxicology, biological effects of pollution
Female
Fundamental and applied biological sciences. Psychology
General aspects
Liver - abnormalities
Liver - drug effects
Male
Organ Size
Pregnancy
rat
Rats
Reproduction - drug effects
reproductive/developmental toxicity
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Summary:Rats were treated by gavage once daily with 2,4-dinitrophenol (DNP) at 0 (control), 3, 10, or 30 mg/kg bw. Males were dosed for 46 days, beginning 14 days before mating, and females were dosed for 40-47 days, from 14 days before mating to day 3 of lactation. No deaths were observed in males and females of any group. A significant decrease in body weight gain and significant increase in liver weight were found in males and females at 30 mg/kg bw/day. The number of live pups on postnatal days (PNDs) 0 and 4, live birth index, and body weight of live male and female pups on PNDs 0 and 1 were significantly lowered at 30 mg/kg bw/day. External and internal examinations of pups revealed no increased incidence of malformations in DNP-treated groups. On the basis of these findings, we concluded that DNP has general and reproductive/developmental toxicity, but not teratogenicity, under the present conditions. The NOAEL of DNP is considered to be 10 mg/kg bw/day in rats.
ISSN:1520-4081
1522-7278
DOI:10.1002/tox.20398