Metabolic syndrome as a risk factor for high-ocular tension

Objective: To investigate the relationship between the metabolic syndrome and intraocular pressure (IOP). Methods: An observational study was conducted in a medical health checkup program at a general hospital. This study involved 14 003 apparently healthy Japanese men and women, 18–83 years of age,...

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Bibliographic Details
Published in:International Journal of Obesity 2010-07, Vol.34 (7), p.1209-1217
Main Authors: Imai, K, Hamaguchi, M, Mori, K, Takeda, N, Fukui, M, Kato, T, Kawahito, Y, Kinoshita, S, Kojima, T
Format: Article
Language:English
Subjects:
Abdomen
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
blood glucose
blood lipids
Blood pressure
Body Mass Index
Complications and side effects
Cross-Sectional Studies
Diabetes
diet-related diseases
disease prevalence
Drugs
Endocrinology
eye diseases
Eye examinations
Female
gender differences
Glaucoma
Glucose
Health care
Hepatology
Hospitals
human diseases
Humans
Hypertension
Immunology
Insulin resistance
Intraocular pressure
Intraocular Pressure - physiology
Japan - epidemiology
Japanese people
Male
Medical sciences
Medicine
men
Metabolic diseases
Metabolic syndrome
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Metabolic syndrome X
Middle Aged
Miscellaneous
nutritional status
Obesity
Obesity - complications
Obesity - epidemiology
Ocular Hypertension - epidemiology
Ocular Hypertension - etiology
Other metabolic disorders
pressure
Prevalence
Risk Factors
triacylglycerols
Triglycerides
Ultrasonic imaging
women
Young Adult
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Summary:Objective: To investigate the relationship between the metabolic syndrome and intraocular pressure (IOP). Methods: An observational study was conducted in a medical health checkup program at a general hospital. This study involved 14 003 apparently healthy Japanese men and women, 18–83 years of age, with a mean IOP of 14.8 (3.0) mm Hg. IOP was examined by noncontact tonometer. High-ocular tension was defined as IOP >21 mm Hg without optic-disc abnormalities or history of receiving any anti-glaucoma therapy. Modified criteria of the revised National Cholesterol Education Program Adult Treatment Panel III (rATPIII), the new International Diabetes Federation definition, and the Japan Society for The Study of Obesity definition were used to characterize the metabolic syndrome. Air temperature was assessed from the Gifu Meteorological Observatory, Gifu, Japan. Results: In the male and female subjects, mean IOP and the prevalence of high-ocular tension became high in direct correlation with the increased number of metabolic syndrome components. To analyze by logistic regression, the metabolic syndrome defined by rATPIII was positively and maximum temperature was negatively correlated with high-ocular tension in males (adjusted odds ratio: 2.0 [95% confidence interval, CI, 1.43–2.78] and 0.63 [95% CI, 0.54–0.73], respectively) and in females (adjusted odds ratio: 7.09 [95% CI, 3.74–13.43] and 0.67 [95% CI, 0.53–0.87], respectively). Three of five metabolic syndrome components (fasting plasma glucose, blood pressure, and triglycerides) were related to high-ocular tension. Conclusion: The metabolic syndrome is a risk factor for high-ocular tension.
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2010.32