Inhibitory Effects of Baicalein on the Influenza Virus in Vivo Is Determined by Baicalin in the Serum

Baicalein, an extract from Scutellaria baicalensis, was evaluated for its ability to inhibit the influenza virus in vivo. Oral administration of baicalein to BALB/c mice infected with the influenza A/FM1/1/47(H1N1) virus showed significant effects in preventing death, increasing the mean time to dea...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2010/02/01, Vol.33(2), pp.238-243
Main Authors: Xu, Ge, Dou, Jie, Zhang, Lei, Guo, Qinglong, Zhou, Changlin
Format: Article
Language:eng ; jpn
Subjects:
Animals
antiviral activity
Antiviral Agents - blood
Antiviral Agents - therapeutic use
baicalein
baicalin
Cell Line
Cytopathogenic Effect, Viral - drug effects
Dogs
Female
Flavanones - therapeutic use
Flavonoids - blood
Influenza A Virus, H1N1 Subtype - drug effects
Influenza A Virus, H1N1 Subtype - growth & development
Influenza virus
Mice
Mice, Inbred BALB C
Orthomyxoviridae Infections - blood
Orthomyxoviridae Infections - drug therapy
Plant Extracts - therapeutic use
Rats
Rats, Sprague-Dawley
Scutellaria baicalensis
serum pharmacology
Viral Plaque Assay
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Summary:Baicalein, an extract from Scutellaria baicalensis, was evaluated for its ability to inhibit the influenza virus in vivo. Oral administration of baicalein to BALB/c mice infected with the influenza A/FM1/1/47(H1N1) virus showed significant effects in preventing death, increasing the mean time to death, inhibiting lung consolidation, and reducing the lung virus titer in a dose-dependent manner. These effects are believed to be due to baicalin, the metabolite of baicalein in the serum. At a concentration of baicalin 2 μg/ml in overlay medium, it showed significant inhibition in the plaque assay, and the mean IC50 value of baicalin was calculated as 1.2 μg/ml in the cytopathic effect assay. Our results showed that baicalein warrants further research as a potential antiinfluenza viral agent.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.33.238