Neuroprotective Effect of DAHK Peptide in an Occlusive Model of Permanent Focal Ischemia in Rats

This study examined the neuroprotective ability of tetrapeptide l -Asp-Ala-His-Lys (DAHK) in permanent middle cerebral artery occlusion in rats. One DAHK dose (16 mg/kg) or saline solution were i.v. administered 30 min after occlusion and neurological deficit was evaluated at 2, 24, 48, 72 and 96 h...

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Published in:Neurochemical research 2010-02, Vol.35 (2), p.343-347
Main Authors: Díaz-Ruíz, Araceli, Ríos, Camilo, Carvajal-Sotelo, Joselyn, Ortiz-Plata, Alma, Espino-Solis, Gerardo Pavel, Méndez-Armenta, Marisela, Montes, Sergio, Monroy-Noyola, Antonio
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain Ischemia - drug therapy
Cell Biology
Infarction, Middle Cerebral Artery - drug therapy
Neurochemistry
Neurology
Neuroprotective Agents - therapeutic use
Neurosciences
Oligopeptides - therapeutic use
Original Paper
Rats
Rats, Wistar
Stroke - drug therapy
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Summary:This study examined the neuroprotective ability of tetrapeptide l -Asp-Ala-His-Lys (DAHK) in permanent middle cerebral artery occlusion in rats. One DAHK dose (16 mg/kg) or saline solution were i.v. administered 30 min after occlusion and neurological deficit was evaluated at 2, 24, 48, 72 and 96 h using Longa scoring scale. The striatum infarction area was evaluated until 96 h after occlusion in both groups after staining with hematoxylin–eosin. DAHK-treated group showed a significant ( P  
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-009-0060-3