Efficacy, duration, and onset of immunogenicity of a West Nile virus vaccine, live Flavivirus chimera, in horses with a clinical disease challenge model

Summary Reasons for performing study: West Nile virus (WNF) is a Flavivirus responsible for a life‐threatening neurological disease in man and horses. Development of improved vaccines against Flavivirus infections is therefore important. Objectives: To establish that a single immunogenicity dose of...

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Bibliographic Details
Published in:Equine veterinary journal 2007-11, Vol.39 (6), p.491-497
Main Authors: Long, M.T, Gibbs, E.P.J, Mellencamp, M.W, Bowen, R.A, Seino, K.K, Zhang, S, Beachboard, S.E, Humphrey, P.P
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - blood
Chimera
disease prevention
dosage
Dose-Response Relationship, Immunologic
Female
Flavivirus
Flavivirus chimera
horse
horse diseases
Horse Diseases - epidemiology
Horse Diseases - prevention & control
Horses
immune response
intrathecal challenge
live vaccines
Male
Random Allocation
Safety
safety testing
Severity of Illness Index
Time Factors
Treatment Outcome
vaccination
vaccines
Vaccines, Attenuated - administration & dosage
Vaccines, Attenuated - adverse effects
Vaccines, Attenuated - immunology
viral diseases of animals and humans
Viremia - veterinary
Virulence
West Nile Fever - epidemiology
West Nile Fever - prevention & control
West Nile Fever - veterinary
West Nile virus
West Nile virus - immunology
West Nile virus - pathogenicity
West Nile virus vaccine
West Nile Virus Vaccines - administration & dosage
West Nile Virus Vaccines - adverse effects
West Nile Virus Vaccines - immunology
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Summary:Summary Reasons for performing study: West Nile virus (WNF) is a Flavivirus responsible for a life‐threatening neurological disease in man and horses. Development of improved vaccines against Flavivirus infections is therefore important. Objectives: To establish that a single immunogenicity dose of live Flavivirus chimera (WN‐FV) vaccine protects horses from the disease and it induces a protective immune response, and to determine the duration of the protective immunity. Methods: Clinical signs were compared between vaccinated (VACC) and control (CTRL) horses after an intrathecal WNV challenge given at 10 or 28 days, or 12 months post vaccination. Results: Challenge of horses in the immunogenicity study at Day 28 post vaccination resulted in severe clinical signs of WNV infection in 10/10 control (CTRL) compared to 1/20 vaccinated (VACC) horses (P
ISSN:0425-1644
2042-3306
DOI:10.2746/042516407X217416