A carbohydrate fraction, AIP1, from Artemisia iwayomogi down-regulates Fas gene expression and suppresses apoptotic death of the thymocytes induced by 2,3,7,8-tectrachlorodibenzo-p-dioxin

Apoptotic death of mouse thymocytes in vitro, as induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), involves the up-regulation of Fas gene expression, while a carbohydrate fraction, AIP1, from Artemisia iwayomogi suppresses the death of thymocytes in culture along with the down-regulation of Fas...

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Bibliographic Details
Published in:Biotechnology letters 2005-02, Vol.27 (4), p.253-257
Main Authors: Ji, Hee Jung, Yeo, Hee Kyoung, Lee, Nam Hee, Hwang, Jung Suk, Koo, Kyung Ah, Cheong, Seon Woo, Park, Joo Hung, Oh, Gap Soo, Yoon, Chun Sik, Youn, Hyun Joo
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - drug effects
Apoptosis - physiology
Artemisia - metabolism
Artemisia iwayomogi
Biological and medical sciences
Biotechnology
Carbohydrates
Carbohydrates - pharmacology
Cell Survival - drug effects
Cell Survival - physiology
Cells, Cultured
Dioxins - pharmacology
Dose-Response Relationship, Drug
Down-Regulation - drug effects
Down-Regulation - physiology
Drug Interactions
Fas antigen
fas Receptor
Female
Fundamental and applied biological sciences. Psychology
Gene expression
Mice
Mice, Inbred C57BL
Q1
Q2
Receptors, Tumor Necrosis Factor - metabolism
TCDD
Thymocytes
Thymus Gland - drug effects
Thymus Gland - metabolism
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Summary:Apoptotic death of mouse thymocytes in vitro, as induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), involves the up-regulation of Fas gene expression, while a carbohydrate fraction, AIP1, from Artemisia iwayomogi suppresses the death of thymocytes in culture along with the down-regulation of Fas gene expression. We have now investigated whether the AIP1 fraction modulates TCDD-induced thymocyte death. When treated with TCDD and AIP1 fraction together, the thymocytes do not show apoptosis induced by the TCDD treatment. The AIP1 supplementation to the TCDD treatment also down-regulates the TCDD-induced Fas gene up-regulation. These findings indicate that the AIP1 fraction suppresses TCDD-induced thymocyte apoptosis through the modulation of Fas gene expression.
ISSN:0141-5492
1573-6776
DOI:10.1007/s10529-004-8294-2