Rapid shuttling of NF-AT in discrimination of Ca2 plus signals and immunosuppression

It is reported that sustained high concentrations of Ca2positive are required to maintain FN-AT transcription factors in the nucleus, where they participate in Ca2positive-dependent induction of genes required for lymphocyte activation and proliferation.

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Bibliographic Details
Published in:Nature (London) 1996-10, Vol.383 (6603), p.837-840
Main Authors: Timmerman, Luika A, Clipstone, Neil A, Ho, Steffan N, Northrop, Jeffrey P, Crabtree, Gerald R
Format: Article
Language:English
Subjects:
Calcium
Cellular biology
Immunity (Disease)
Lymphocytes
Reagents
Online Access:Get full text
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Description
Summary:It is reported that sustained high concentrations of Ca2positive are required to maintain FN-AT transcription factors in the nucleus, where they participate in Ca2positive-dependent induction of genes required for lymphocyte activation and proliferation.
ISSN:0028-0836
1476-4687
DOI:10.1038/383837a0