Maternal intake of vitamin D during pregnancy and risk of advanced beta cell autoimmunity and type 1 diabetes in offspring

Aims/hypothesis We evaluated the intake of vitamin D by pregnant Finnish women and examined associations between maternal intake of vitamin D and the development of advanced beta cell autoimmunity and type 1 diabetes in their offspring. Methods The research was carried out within the Diabetes Predic...

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Bibliographic Details
Published in:Diabetologia 2010-08, Vol.53 (8), p.1599-1607
Main Authors: Marjamäki, L, Niinistö, S, Kenward, M. G, Uusitalo, L, Uusitalo, U, Ovaskainen, M.-L, Kronberg-Kippilä, C, Simell, O, Veijola, R, Ilonen, J, Knip, M, Virtanen, S. M
Format: Article
Language:English
Subjects:
Autoantibodies - immunology
Autoimmunity - immunology
Beta cell autoimmunity
Biological and medical sciences
Chi-Square Distribution
children
Cohort
Diabetes
Diabetes Mellitus, Type 1 - etiology
Diabetes Mellitus, Type 1 - immunology
Diabetes. Impaired glucose tolerance
Dietary Supplements
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Families & family life
Female
Finland
Fish oils
Food
Health risk assessment
Human Physiology
Humans
Infant
insulin-dependent diabetes mellitus
Insulin-Secreting Cells - immunology
Internal Medicine
Maternal-Fetal Exchange
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Pediatrics
Population-based studies
Pregnancy
Proportional Hazards Models
Public health
Surveys and Questionnaires
Vitamin D
Vitamin D - administration & dosage
Vitamin D - immunology
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Summary:Aims/hypothesis We evaluated the intake of vitamin D by pregnant Finnish women and examined associations between maternal intake of vitamin D and the development of advanced beta cell autoimmunity and type 1 diabetes in their offspring. Methods The research was carried out within the Diabetes Prediction and Prevention study (DIPP), which is a population-based birth cohort of infants at genetic risk of type 1 diabetes. Mothers of 3,723 infants born between 1997 and 2002 completed a validated 181-item food frequency questionnaire, which included questions on dietary supplements. The offspring were observed at 3 to 12 month intervals for the appearance of autoantibodies associated with type 1 diabetes and for the development of clinical type 1 diabetes. Results Maternal mean daily intake of vitamin D was 5.1 µg from food and 1.3 µg from supplements. The maternal intake of vitamin D, either from food or from supplements, was not associated with the risk of advanced beta cell autoimmunity/type 1 diabetes in offspring (HR [95% CI] for intake of vitamin D from food 1.25 [0.80-1.95], for vitamin D intake from supplements 1.05 [0.95-1.16]), or with the risk of type 1 diabetes alone (HR [95% CI] for intake of vitamin D from food 0.84 [0.41-1.72], for vitamin D intake from supplements 1.09 [0.99-1.20]). Conclusions/interpretation Maternal intake of vitamin D either from food or supplements during pregnancy is not associated with advanced beta cell autoimmunity/type 1 diabetes or with type 1 diabetes alone in Finnish offspring carrying increased genetic susceptibility to type 1 diabetes.
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-010-1734-8