The effects of transdermal permeation enhancers on thermotropic phase behaviour of a stratum corneum lipid model

This study evaluates the interactions of a model stratum corneum (SC) lipid system based on ceramide AP ( N-(2-hydroxystearoyl)phytosphingosine) with three selected permeation enhancers including urea, oleic acid (OA), and N-lauroylglycine lauryl ester (12G12) using temperature-dependent small-angle...

Full description

Saved in:
Bibliographic Details
Published in:Colloids and surfaces. A, Physicochemical and engineering aspects Physicochemical and engineering aspects, 2009-11, Vol.351 (1), p.30-37
Main Authors: Zbytovská, J., Vávrová, K., Kiselev, M.A., Lessieur, P., Wartewig, S., Neubert, R.H.H.
Format: Article
Language:English
Subjects:
Ceramide analogue
Oleic acid
Small-angle X-ray diffraction
Stratum corneum lipids
Thermotropic phase behaviour
Urea
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study evaluates the interactions of a model stratum corneum (SC) lipid system based on ceramide AP ( N-(2-hydroxystearoyl)phytosphingosine) with three selected permeation enhancers including urea, oleic acid (OA), and N-lauroylglycine lauryl ester (12G12) using temperature-dependent small-angle X-ray diffraction measurements. As a first step, the thermotropic phase behaviour of the control SC lipid membrane, i.e. without enhancer, was characterized. The system shows two separated phases at 32 °C, which mix into another phase at around 45 °C. This phase is stable till 70 °C when the repeat distance starts to decrease. After cooling, only one phase is visible which shows two phase transitions at 45 and 70 °C again. Based on these results, the effects of the permeation enhancers were studied. The permeation enhancers influence the phase behaviour of the system. Urea and 12G12 cause a concentration-dependent shift of the phase transition temperatures while OA induces a phase separation. The results from this simple model system may provide basis for studies on more complex systems or real SC.
ISSN:0927-7757
1873-4359
DOI:10.1016/j.colsurfa.2009.09.025