Effect of Neuroleptic Haloperidol, L-DOPA Precursor Dopamine, and Neurotoxic Dopamine Analog 6-OHDA on Acquisition of Conditioned Defensive Reflex in Edible Snail

The effect of neuroleptic haloperidol, a dopamine precursor L-DOPA, and dopamine analog 6-OHDA on the development of conditioned defensive reflex was studied in edible snails. Injection of L-DOPA to intact snails and to snails pretreated with 6-OHDA 2 h before learning session decelerated acquisitio...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2009-11, Vol.148 (5), p.750-753
Main Authors: Muranova, L. N, Andrianov, V. V, Gainutdinov, Kh. L
Format: Article
Language:English
Subjects:
Animals
Antipsychotic Agents - pharmacology
Behavior, Animal - drug effects
Biomedical and Life Sciences
Biomedicine
Cell Biology
conditioned defensive reflex
Conditioning, Classical - drug effects
dopamine
Dopamine - pharmacology
Dopamine Agents - pharmacology
Dopamine Antagonists - pharmacology
haloperidol
Haloperidol - pharmacology
Helix (Snails) - drug effects
Helix (Snails) - physiology
Internal Medicine
L-DOPA, 6-OHDA
Laboratory Medicine
Oxidopamine - pharmacology
Pathology
Physiology
Sympatholytics - pharmacology
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Summary:The effect of neuroleptic haloperidol, a dopamine precursor L-DOPA, and dopamine analog 6-OHDA on the development of conditioned defensive reflex was studied in edible snails. Injection of L-DOPA to intact snails and to snails pretreated with 6-OHDA 2 h before learning session decelerated acquisition of the conditioned reflex and exerted a toxic action. In contrast, injection of 6-OHDA or haloperidol did not affect acquisition of the conditioned reflex.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-0808-4