Angiogenesis and expression of estrogen and progesterone receptors as predictive factors for recurrence of meningioma

Meningiomas are benign tumors, with low rate of recurrence after surgery. The most important factor predicting recurrence is the extent of surgical resection; other factors have been studied with conflicting results. Angiogenesis, an important substratum for growth and spread of neoplasic cells, and...

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Bibliographic Details
Published in:Journal of neuro-oncology 2010-07, Vol.98 (3), p.379-384
Main Authors: Guevara, Patricia, Escobar-Arriaga, Elizabeth, Saavedra-Perez, David, Martinez-Rumayor, Abelardo, Flores-Estrada, Diana, Rembao, Daniel, Calderon, Alejandra, Sotelo, Julio, Arrieta, Oscar
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Clinical Study - Patient Study
Cohort Studies
Cyclin E - metabolism
Female
Humans
Male
Medicine
Medicine & Public Health
Meningeal Neoplasms - complications
Meningeal Neoplasms - metabolism
Meningeal Neoplasms - pathology
Meningioma - complications
Meningioma - metabolism
Meningioma - pathology
Middle Aged
Neoplasm Recurrence, Local - diagnosis
Neovascularization, Pathologic - etiology
Neurology
Oncology
Receptors, Estrogen - metabolism
Receptors, Progesterone - metabolism
Retrospective Studies
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Summary:Meningiomas are benign tumors, with low rate of recurrence after surgery. The most important factor predicting recurrence is the extent of surgical resection; other factors have been studied with conflicting results. Angiogenesis, an important substratum for growth and spread of neoplasic cells, and the expression of estrogen and progesterone receptors (ER, PR), could play a role in the recurrence of meningioma. We evaluated 42 patients with meningioma diagnosis (confirmed by histopathology) treated exclusively by surgery between January 1995 and December 1999, and compared the recurring and non-recurring groups after a ten-year follow-up period. Recurrence was associated with several factors including vascular density (VD), cell proliferation index (CPI), ER, PR, and cyclin E (CE) tissue expression, as evaluated by immunohistochemistry. Complete surgical resection was achieved in 41% of patients. Recurrence of meningioma was found in 17 patients (40%). Median ± standard deviation (SD) of recurrence time was 32 ± 5 months. When recurrence versus no recurrence was compared, mean ± SD of VD and CPI were 9 ± 3.6 and 607.6 ± 233 (40×/10 fields) respectively. Tissue expression was positive for ER, PR, and CE in 28, 62 and 91% of patients, respectively. The sole significant recurrence-associated factors were extent of resection ( P  = 0.003) and VD ( P  = 0.004). ER, PR, and CE-tissue expression were not statistically significant. The most important factor associated with meningioma relapse was vascular density, independently of hormonal status and extent of surgical resection. Patients with a high risk of recurrence could benefit from additional treatment.
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-009-0086-z