Inhibitory effect of ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on memory impairment and neuronal toxicity induced by beta-amyloid

The components of the herb Magnolia officinalis have exhibited antioxidant and neuroprotective activities. In this study, we investigated effects of ethanol extract of M. officinalis and its major component 4- O-methylhonokiol on memory dysfunction and neuronal cell damages caused by Aβ. Oral pretre...

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Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2010-03, Vol.95 (1), p.31-40
Main Authors: Lee, Jae Woong, Lee, Yong Kyung, Lee, Beom Jun, Nam, Sang-Yoon, Lee, Sang Il, Kim, Young Heui, Kim, Ki Ho, Oh, Ki-Wan, Hong, Jin Tae
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Alzheimer's disease
Animals
Beta-amyloid peptide
Biological and medical sciences
Biphenyl Compounds - pharmacology
Blotting, Western
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Ethanol - chemistry
Fluorescence
Lignans - pharmacology
Magnolia
Magnolia - chemistry
Male
Medical sciences
Memory - drug effects
Memory, 4- O-methylhonokiol
Mice
Mice, Inbred ICR
Neurology
Neurons - drug effects
Neurons - metabolism
Organic mental disorders. Neuropsychology
PC12 Cells
Plant Extracts - pharmacology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Rats
Reactive Oxygen Species - metabolism
ROS
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Summary:The components of the herb Magnolia officinalis have exhibited antioxidant and neuroprotective activities. In this study, we investigated effects of ethanol extract of M. officinalis and its major component 4- O-methylhonokiol on memory dysfunction and neuronal cell damages caused by Aβ. Oral pretreatment of ethanol extract of M. officinalis (2.5, 5 and 10 mg/kg) and 4- O-methylhonokiol (1 mg/kg) into drinking water for 5 weeks suppressed the intraventricular treatment of Aβ 1–42 (0.5 μg/mouse, i.c.v.)-induced memory impairments. In addition, 4- O-methylhonokiol prevented the Aβ 1–42-induced apoptotic cell death as well as β-secretase expression. 4- O-methylhonokiol also inhibited H 2O 2 and Aβ 1–42-induced neurotoxicity in cultured neurons as well as PC12 cells by prevention of the reactive oxygen species generation. 4- O-methylhonokiol also directly inhibited β-secretase activity and Aβ fibrilization in vitro. Thus, ethanol extract of M. officinalis may be useful for prevention of the development or progression of AD, and 4- O-methylhonokiol may be a major active component.
ISSN:0091-3057
1873-5177
DOI:10.1016/j.pbb.2009.12.003