HPV infection in an HIV-positive patient with primary squamous cell carcinoma of rectum

Primary squamous cell carcinoma (SCC) of the colorectum is a rare malignancy of unknown etiology and pathogenesis. We report a case of primary SCC of the rectum. A 55-year-old man with a rectal tumor and human immunodeficiency virus (HIV) infection was referred to our hospital. Histopathology of bio...

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Bibliographic Details
Published in:International journal of clinical oncology 2009-12, Vol.14 (6), p.551-554
Main Authors: Matsuda, Akihisa, Takahashi, Keiichi, Yamaguchi, Tatsuro, Matsumoto, Hiroshi, Miyamoto, Hidenori, Kawakami, Masayo, Kawachi, Hiroshi, Suzuki, Hideyuki, Furukawa, Kiyonori, Tajiri, Takashi, Mori, Takeo
Format: Article
Language:English
Subjects:
Cancer Research
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - virology
Case Report
Case studies
Colorectal cancer
HIV
HIV Infections - complications
Human immunodeficiency virus
Human papillomavirus
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Papillomavirus Infections - complications
Pathogenesis
Rectal Neoplasms - diagnosis
Rectal Neoplasms - pathology
Rectal Neoplasms - virology
Rectum - pathology
Rectum - virology
Surgical Oncology
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Summary:Primary squamous cell carcinoma (SCC) of the colorectum is a rare malignancy of unknown etiology and pathogenesis. We report a case of primary SCC of the rectum. A 55-year-old man with a rectal tumor and human immunodeficiency virus (HIV) infection was referred to our hospital. Histopathology of biopsy specimens showed characteristics of SCC. We diagnosed the patient as having primary moderately differentiated SCC of the rectum according to the criteria proposed by Cooper. Human papillomavirus (HPV) DNA was amplified by polymerase chain reaction analysis of unfixed tumor biopsy specimens. In addition, no p53 overexpression or nuclear staining of retinoblastoma protein (Rb) was observed in neoplastic cells by immunohistochemical staining. We suggest from our case that HPV infection following the inactivation of the cellular tumor suppressor Rb and the immune suppression induced by HIV infection play an etiologic role in the pathogenesis of rectal SCC, consistent with the well-established concept of HPV-associated anal carcinogenesis.
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-009-0890-7