Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis

In the absence of disease, the vasculature of the mammalian eye is quiescent, in part because of the action of angiogenic inhibitors that prevent vessels from invading the cornea and vitreous. Here, an inhibitor responsible for the avascularity of these ocular compartments is identified as pigment e...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1999-07, Vol.285 (5425), p.245-248
Main Authors: Dawson, D. W., Volpert, O. V., Gillis, P., Crawford, S. E., H.-J. Xu, Benedict, W., Bouck, N. P.
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Animals, Newborn
Antibodies
Antibodies - immunology
Biological and medical sciences
Blindness
Blood vessels
Cattle
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Cells
Cells, Cultured
Chemotaxis - drug effects
Cornea
Culture Media, Conditioned
Diabetes
Disease
Endothelial cells
Endothelial Growth Factors - metabolism
Endothelium, Vascular - cytology
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiology
Eye - blood supply
Eye Proteins
Eyes & eyesight
Fundamental and applied biological sciences. Psychology
Humans
Hypoxia
Individualized Instruction
Lymphokines - metabolism
Mice
Migration
Molecular and cellular biology
Neonates
Neovascularization
Neovascularization, Pathologic - drug therapy
Neovascularization, Pathologic - metabolism
Neovascularization, Pathologic - pathology
Neovascularization, Physiologic - drug effects
Nerve Growth Factors
Oxygen
Oxygen - physiology
Photoreceptors
Proteins
Proteins - genetics
Proteins - immunology
Proteins - pharmacology
Proteins - physiology
Rats
Retina
Retina - metabolism
Retina - pathology
Retinal Neovascularization - drug therapy
Retinal Vessels - growth & development
RNA, Messenger - genetics
RNA, Messenger - metabolism
Serpins - genetics
Serpins - immunology
Serpins - pharmacology
Serpins - physiology
Tumor Cells, Cultured
Tumors
Ungulates
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Visual Acuity
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Description
Summary:In the absence of disease, the vasculature of the mammalian eye is quiescent, in part because of the action of angiogenic inhibitors that prevent vessels from invading the cornea and vitreous. Here, an inhibitor responsible for the avascularity of these ocular compartments is identified as pigment epithelium-derived factor (PEDF), a protein previously shown to have neurotrophic activity. The amount of inhibitory PEDF produced by retinal cells was positively correlated with oxygen concentrations, suggesting that its loss plays a permissive role in ischemia-driven retinal neovascularization. These results suggest that PEDF may be of therapeutic use, especially in retinopathies where pathological neovascularization compromises vision and leads to blindness.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.285.5425.245