Two-amino acid molecular switch in an epithelial morphogen that regulated binding to two distinct receptors

Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth.

Bibliographic Details

Published in:	Science (American Association for the Advancement of Science) 2000-10, Vol.290 (5491), p.523-527
Main Authors:	Yan, Minhong, Li-Chong, Wang, Hymowitz, Sarah G, Schilbach, Sarah
Format:	Article
Language:	English
Subjects:	Amino acids Molecules Mutation
Online Access:	Get full text
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