Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China

A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyct...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) 2003-10, Vol.302 (5643), p.276-278
Main Authors:	Guan, Y., Zheng, B. J., He, Y. Q., Liu, X. L., Zhuang, Z. X., Cheung, C. L., Luo, S. W., Li, P. H., Zhang, L. J., Guan, Y. J., Butt, K. M., Wong, K. L., Chan, K. W., Lim, W., Shortridge, K. F., Yuen, K. Y., Peiris, J. S. M., Poon, L. L. M.
Format:	Article
Language:	eng
Subjects:	Amino Acid Sequence Animals Animals, Wild - virology Antibodies Antibodies, Viral - blood Biological and medical sciences Blotting, Western Carnivora - virology Causes of China Coronavirus Coronavirus - classification Coronavirus - genetics Coronavirus - immunology Coronavirus - isolation & purification Coronavirus Infections - veterinary Coronavirus Infections - virology Coronaviruses Disease Reservoirs Epidemics Feces - virology Genetic aspects Genome, Viral Human viral diseases Humans Infections Infectious diseases Medical sciences Membrane Glycoproteins - chemistry Membrane Glycoproteins - genetics Molecular Sequence Data Neutralization Tests Nose - virology Nucleotides Open reading frames Open Reading Frames - genetics Patients Phylogeny Polymorphism, Genetic Public health Reverse Transcriptase Polymerase Chain Reaction SARS SARS Virus - classification SARS Virus - genetics SARS Virus - immunology SARS Virus - isolation & purification Sequence Deletion Sequence Homology, Nucleic Acid Severe acute respiratory syndrome Spike Glycoprotein, Coronavirus Viral diseases Viral diseases of the respiratory system and ent viral diseases Viral Envelope Proteins - chemistry Viral Envelope Proteins - genetics Viral Proteins - chemistry Viral Proteins - genetics Virus diseases Viruses Wild animals
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Summary:	A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.
ISSN:	0036-8075 1095-9203